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 Previous Article

Journal of Bacteriology, January 2007, p. 663-669, Vol. 189, No. 2
0021-9193/07/$08.00+0     doi:10.1128/JB.01638-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Expression of the Iron-Activated nspA and secY Genes in Neisseria meningitidis Group B by Fur-Dependent and -Independent Mechanisms{triangledown}

Yazdani B. Shaik,1 Susan Grogan,1 Michael Davey,2 Shite Sebastian,1 Sulip Goswami,1 Borys Szmigielski,1 and Caroline A. Genco1,2,3*

Department of Medicine, Section of Molecular Medicine, Boston University School of Medicine, Boston, Massachusetts 02118,1 Department of Oral Biology, Boston University Goldman School of Dental Medicine, Boston, Massachusetts 02118,2 Department of Microbiology, Boston University School of Medicine, Boston Massachusetts 021183

Received 20 October 2006/ Accepted 26 October 2006

Our whole-genome microarray studies of Neisseria meningitidis MC58 previously identified a set of 153 genes whose transcription was activated during growth in iron. In this study, Fur-mediated regulation of the iron-activated nspA gene was confirmed, whereas iron-activated regulation of the secY gene was demonstrated to be Fur independent. Analysis of the Fur binding sequences in the nspA gene and an additional iron-activated and Fur-regulated gene identified a hexameric (G/T)ATAAT unit in the operator regions of these genes similar to that observed in Fur- and iron-repressed genes. These studies indicate that the expression of the iron-activated nspA and secY genes in N. meningitidis occur by Fur-dependent and -independent mechanisms, respectively.

* Corresponding author. Mailing address: Department of Medicine, Section of Molecular Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118. Phone: (617) 414-5305. Fax: (617) 414-5280. E-mail: cgenco{at}bu.educaroline.genco{at}bmc.org.

{triangledown} Published ahead of print on 3 November 2006.

Journal of Bacteriology, January 2007, p. 663-669, Vol. 189, No. 2
0021-9193/07/$08.00+0     doi:10.1128/JB.01638-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Agarwal, S., Sebastian, S., Szmigielski, B., Rice, P. A., Genco, C. A. (2008). Expression of the Gonococcal Global Regulatory Protein Fur and Genes Encompassing the Fur and Iron Regulon during In Vitro and In Vivo Infection in Women. J. Bacteriol. 190: 3129-3139 [Abstract] [Full Text]  
  • Mellin, J. R., Goswami, S., Grogan, S., Tjaden, B., Genco, C. A. (2007). A Novel Fur- and Iron-Regulated Small RNA, NrrF, Is Required for Indirect Fur-Mediated Regulation of the sdhA and sdhC Genes in Neisseria meningitidis. J. Bacteriol. 189: 3686-3694 [Abstract] [Full Text]  


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