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Journal of Bacteriology, October 2007, p. 7515-7519, Vol. 189, No. 20
0021-9193/07/$08.00+0     doi:10.1128/JB.00547-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Sequence Analysis of the Staphylococcus aureus srrAB Loci Reveals that Truncation of srrA Affects Growth and Virulence Factor Expression{triangledown}

Alexa A. Pragman, Lisa Herron-Olson, Laura C. Case, Sara M. Vetter, Evan E. Henke, Vivek Kapur, and Patrick M. Schlievert*

Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455

Received 10 April 2007/ Accepted 24 July 2007

The SrrAB system regulates metabolism and virulence factors in Staphylococcus aureus. We sequenced the srrAB loci of 21 isolates and performed a phylogenetic analysis. Vaginal and bovine isolates clustered together, while skin isolates were genetically diverse. Few nucleotide polymorphisms were observed, and most were synonymous. Two strains (N2 and N19) with N-terminal truncations in SrrA displayed defects in growth and abnormally upregulated virulence factor expression under low-oxygen conditions.

* Corresponding author. Mailing address: Department of Microbiology, University of Minnesota Medical School, 420 Delaware St. SE, MMC 196, Minneapolis, MN 55455. Phone: (612) 624-9471. Fax: (612) 626-0623. E-mail: schli001{at}umn.edu

{triangledown} Published ahead of print on 10 August 2007.

Journal of Bacteriology, October 2007, p. 7515-7519, Vol. 189, No. 20
0021-9193/07/$08.00+0     doi:10.1128/JB.00547-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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