This Article Full Text Full Text (PDF) Other Versions of this Article: JB.00981-07v1 189/21/7581    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Russell, J. H. Articles by Keiler, K. C. Search for Related Content PubMed PubMed Citation Articles by Russell, J. H. Articles by Keiler, K. C.

Peptide Signals Encode Protein Localization

Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802

Received 20 June 2007/ Accepted 23 August 2007

Many bacterial proteins are localized to precise intracellular locations, but in most cases the mechanism for encoding localization information is not known. Screening libraries of peptides fused to green fluorescent protein identified sequences that directed the protein to helical structures or to midcell. These peptides indicate that protein localization can be encoded in 20-amino-acid peptides instead of complex protein-protein interactions and raise the possibility that the location of a protein within the cell could be predicted from bioinformatic data.

Published ahead of print on 31 August 2007.