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Journal of Bacteriology, November 2007, p. 7922-7926, Vol. 189, No. 21
0021-9193/07/$08.00+0     doi:10.1128/JB.00461-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Deoxycytidine Pathway for Thymidylate Synthesis in Escherichia coli{triangledown}

Bernard Weiss*

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322

Received 27 March 2007/ Accepted 24 August 2007

When thymidylate production is diminished by a mutation affecting dCTP deaminase, Escherichia coli is known to use an alternate pathway involving deoxycytidine as an intermediate. The pathway requires the gene for any of three nucleoside diphosphate kinases (ndk, pykA, or pykF) and the gene for a 5'-nucleotidase (yfbR).

* Mailing address: Department of Pathology and Laboratory Medicine, Emory University, Whitehead Bldg., Rm. 141, 615 Michael St., Atlanta, GA 30322. Phone: (404) 712-2812. Fax: (404) 727-8538. E-mail: bweiss2{at}emory.edu

{triangledown} Published ahead of print on 7 September 2007.

Journal of Bacteriology, November 2007, p. 7922-7926, Vol. 189, No. 21
0021-9193/07/$08.00+0     doi:10.1128/JB.00461-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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