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Effect of a Small, Acid-Soluble Spore Protein from Clostridium perfringens on the Resistance Properties of Bacillus subtilis Spores

Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut 06030-3305,¹ Department of Biomedical Sciences, College of Veterinary Medicine,² Department of Microbiology, Oregon State University, Corvallis, Oregon 97331³

Received 25 July 2007/ Accepted 22 August 2007

/ß-type small, acid-soluble spore proteins (SASP) are essential for the resistance of DNA in spores of Bacillus species to damage. An /ß-type SASP, Ssp2, from Clostridium perfringens was expressed at significant levels in B. subtilis spores lacking one or both major /ß-type SASP (^– and ^– ß^– strains, respectively). Ssp2 restored some of the resistance of ^– ß^– spores to UV and nitrous acid and of ^– spores to dry heat. Ssp2 also restored much of the resistance of ^– spores to nitrous acid and restored full resistance of ^– spores to UV and moist heat. These results further indicate the interchangeability of /ß-type SASP in DNA protection in spores.

Published ahead of print on 31 August 2007.

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