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Journal of Bacteriology, November 2007, p. 8377-8380, Vol. 189, No. 22
0021-9193/07/$08.00+0     doi:10.1128/JB.01199-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Regulation of Expression of the Fibronectin-Binding Protein BBK32 in Borrelia burgdorferi{triangledown}

Ming He, Bethany K. Boardman, Dalai Yan, and X. Frank Yang*

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202

Received 26 July 2007/ Accepted 5 September 2007

The BBK32 protein binds to host extracellular ligand fibronectin and contributes to the pathogenesis of Borrelia burgdorferi. Here we showed that expression of the BBK32 gene is influenced by multiple environmental factors and that its regulation is governed by the response regulator Rrp2 and RpoN-RpoS ({sigma}54-{sigma}S) sigma cascade in B. burgdorferi.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202. Phone: (317) 274-7671. Fax: (317) 274-4090. E-mail: xfyang{at}iupui.edu

{triangledown} Published ahead of print on 14 September 2007.

Journal of Bacteriology, November 2007, p. 8377-8380, Vol. 189, No. 22
0021-9193/07/$08.00+0     doi:10.1128/JB.01199-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ouyang, Z., Blevins, J. S., Norgard, M. V. (2008). Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi. Microbiology 154: 2641-2658 [Abstract] [Full Text]  


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