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Journal of Bacteriology, December 2007, p. 9117-9121, Vol. 189, No. 24
0021-9193/07/$08.00+0     doi:10.1128/JB.01049-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Streptomyces coelicolor Undergoes Spontaneous Chromosomal End Replacement{triangledown} ,{dagger}

Elizabeth M. Widenbrant,1* Hsiu-Hui Tsai,2 Carton W. Chen,2 and Camilla M. Kao1

Department of Chemical Engineering, Stanford University, Stanford California 94305,1 Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Shih-Pai, Taipei 112, Taiwan2

Received 3 July 2007/ Accepted 9 October 2007

We report a previously unobserved form of genetic instability for Streptomyces coelicolor, the replacement of one chromosome end by the other end. These genetic changes occurred spontaneously in both a wild-type strain and strains harboring a foreign transposon. Deleted and duplicated DNA comprises up to 33% of the genome.

* Corresponding author. Mailing address: Department of Chemical Engineering, Stanford University, Stanford, CA 94305. Phone: (650) 723-4906. Fax: (650) 723-9780. E-mail: ewidenbrant{at}gmail.com

{triangledown} Published ahead of print on 19 October 2007.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, December 2007, p. 9117-9121, Vol. 189, No. 24
0021-9193/07/$08.00+0     doi:10.1128/JB.01049-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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