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Transmembrane Helix 12 of the Staphylococcus aureus Multidrug Transporter QacA Lines the Bivalent Cationic Drug Binding Pocket

School of Biological Sciences, The University of Sydney, Sydney, New South Wales, Australia,¹ School of Biological Sciences, Flinders University, Adelaide, South Australia, Australia²

Received 17 September 2007/ Accepted 5 October 2007

An acidic residue in transmembrane segment (TMS) 10 is important for recognition of bivalent cationic substrates by the QacA multidrug transporter. Remarkably, an acidic residue in TMS 12 compensated for the absence of such a residue in TMS 10, suggesting that TMS 12 is a component of the bivalent cation-binding region.

Published ahead of print on 19 October 2007.

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