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Journal of Bacteriology, December 2007, p. 9135-9139, Vol. 189, No. 24
0021-9193/07/$08.00+0     doi:10.1128/JB.00847-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Pinholin of Lambdoid Phage 21: Control of Lysis by Membrane Depolarization{triangledown}

Taehyun Park, Douglas K. Struck, Chelsey A. Dankenbring, and Ry Young*

Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, Texas 77843-2128

Received 31 May 2007/ Accepted 17 August 2007

The phage 21 holin, S21, forms small membrane holes that depolarize the membrane and is designated as a pinholin, as opposed to large-hole-forming holins, like S{lambda}. Pinholins require secreted SAR endolysins, a pairing that may represent an intermediate in the evolution of canonical holin-endolysin systems.

* Corresponding author. Mailing address: Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, TX 77843-2128. Phone: (979) 845-2087. Fax: (979) 862-4718. E-mail: ryland{at}tamu.edu

{triangledown} Published ahead of print on 7 September 2007.

Journal of Bacteriology, December 2007, p. 9135-9139, Vol. 189, No. 24
0021-9193/07/$08.00+0     doi:10.1128/JB.00847-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Pang, T., Savva, C. G., Fleming, K. G., Struck, D. K., Young, R. (2009). Structure of the lethal phage pinhole. Proc. Natl. Acad. Sci. USA 106: 18966-18971 [Abstract] [Full Text]  
  • Zheng, Y., Struck, D. K., Dankenbring, C. A., Young, R. (2008). Evolutionary dominance of holin lysis systems derives from superior genetic malleability. Microbiology 154: 1710-1718 [Abstract] [Full Text]  


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