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YhbO Protects Cells against Multiple Stresses

Jad Abdallah,^1, Teresa Caldas,^1, Fatoum Kthiri,² Renée Kern,¹ and Gilbert Richarme^1*

Stress Molecules, Institut Jacques Monod, Université Paris 7, 2 Place Jussieu, 75005 Paris, France,¹ Laboratoire de Biochimie et Biologie Moléculaire, 03/UR/0902, Faculté des Sciences de Bizerte, Zarzouna 7021, Bizerte, Tunisia²

Received 27 July 2007/ Accepted 2 October 2007

YhbO is a member of the DJ-1/ThiJ/Pfp1 superfamily, which includes chaperones, peptidases, and the Parkinson's disease protein DJ-1. A yhbO-disrupted mutant of Escherichia coli is highly sensitive to oxidative, thermal, UV, and pH stresses, and the putative nucleophilic cysteine C104 of YhbO is required for stress resistance. These results suggest that YhbO affects a central process in stress management.

Published ahead of print on 12 October 2007.

J.A. and T.C. contributed equally to the work, and the order of their names was arbitrarily chosen.