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Journal of Bacteriology, December 2007, p. 9145-9149, Vol. 189, No. 24
0021-9193/07/$08.00+0     doi:10.1128/JB.00722-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Genetic Diversity of the Gene Cluster Encoding Longus, a Type IV Pilus of Enterotoxigenic Escherichia coli{triangledown} ,{dagger}

Oscar G. Gomez-Duarte,1* Sujay Chattopadhyay,2 Scott J. Weissman,3 Jorge A. Giron,4 James B. Kaper,5 and Evgeni V. Sokurenko2*

Division of Infectious Diseases, Department of Pediatrics, University of Iowa Children's Hospital, Iowa City, Iowa,1 Department of Microbiology, University of Washington, Seattle, Washington,2 Division of Infectious Disease, Immunology, and Rheumatology, Department of Pediatrics, University of Washington, Seattle, Washington,3 Department of Immunobiology, University of Arizona, Tucson, Arizona,4 Department of Microbiology, University of Maryland, Baltimore, Maryland5

Received 7 May 2007/ Accepted 20 September 2007

Enterotoxigenic Escherichia coli (ETEC) strains produce a type IV pilus named Longus. We identified a 16-gene cluster involved in the biosynthesis of Longus that has 57 to 95% identity at the protein level to CFA/III, another type IV pilus of ETEC. Alleles of the Longus structural subunit gene lngA demonstrate a diversity of 12 to 19% at the protein level with strong positive selection for point replacements and horizontal transfer.

* Corresponding author. Mailing address for Oscar G. Gomez-Duarte: Division of Pediatric Infectious Diseases, University of Iowa Children's Hospital, 200 Hawkins Drive, Iowa City, IA 52242. Phone: (319) 356-2270. Fax: (319) 356-4855. E-mail: oscar-gomez{at}uiowa.edu. Mailing address for Evgeni V. Sokurenko: Department of Microbiology, University of Washington, Seattle, WA 98195-7242. Phone: (206) 685-2162. Fax: (206) 543-8297. E-mail: evs{at}u.washington.edu

{triangledown} Published ahead of print on 19 October 2007.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, December 2007, p. 9145-9149, Vol. 189, No. 24
0021-9193/07/$08.00+0     doi:10.1128/JB.00722-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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