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Journal of Bacteriology, February 2007, p. 1163-1170, Vol. 189, No. 3
0021-9193/07/$08.00+0     doi:10.1128/JB.01343-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Bacillus subtilis Genome Diversity{triangledown} ,{dagger}

Ashlee M. Earl,1 Richard Losick,2 and Roberto Kolter1*

Department of Microbiology & Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115,1 Department of Molecular & Cellular Biology, The Biological Laboratories, Harvard University, 16 Divinity Ave., Cambridge, Massachusetts 021382

Received 23 August 2006/ Accepted 7 November 2006

Microarray-based comparative genomic hybridization (M-CGH) is a powerful method for rapidly identifying regions of genome diversity among closely related organisms. We used M-CGH to examine the genome diversity of 17 strains belonging to the nonpathogenic species Bacillus subtilis. Our M-CGH results indicate that there is considerable genetic heterogeneity among members of this species; nearly one-third of Bsu168-specific genes exhibited variability, as measured by the microarray hybridization intensities. The variable loci include those encoding proteins involved in antibiotic production, cell wall synthesis, sporulation, and germination. The diversity in these genes may reflect this organism's ability to survive in diverse natural settings.

* Corresponding author. Mailing address: Department of Microbiology & Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115. Phone: (617) 432-1776. Fax: (617) 738-7664. E-mail: rkolter{at}hms.harvard.edu.

{triangledown} Published ahead of print on 17 November 2006.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, February 2007, p. 1163-1170, Vol. 189, No. 3
0021-9193/07/$08.00+0     doi:10.1128/JB.01343-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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