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Journal of Bacteriology, February 2007, p. 1459-1463, Vol. 189, No. 4
0021-9193/07/$08.00+0     doi:10.1128/JB.01026-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Unraveling the Regulatory Network in Streptococcus pyogenes: the Global Response Regulator CovR Represses rivR Directly{triangledown}

Samantha A. Roberts, Gordon G. Churchward, and June R. Scott*

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322

Received 12 July 2006/ Accepted 28 August 2006

The response regulator CovR acts as a master regulator of virulence in Streptococcus pyogenes by repressing transcription of approximately 15% of the group A streptococcus genome directly or indirectly. We demonstrate that phosphorylated CovR represses transcription of rivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase. This establishes the first link in a regulatory network where CovR interacts directly with other proteins that modulate gene expression.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322. Phone: (404) 727-0402. Fax: (404) 727-8999. E-mail: scott{at}microbio.emory.edu.

{triangledown} Published ahead of print on 8 September 2006.

Journal of Bacteriology, February 2007, p. 1459-1463, Vol. 189, No. 4
0021-9193/07/$08.00+0     doi:10.1128/JB.01026-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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