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Journal of Bacteriology, February 2007, p. 1473-1477, Vol. 189, No. 4
0021-9193/07/$08.00+0     doi:10.1128/JB.01227-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Complete Genome of Acute Rheumatic Fever-Associated Serotype M5 Streptococcus pyogenes Strain Manfredo{triangledown}

Matthew T. G. Holden,1* Annabel Scott,1 Inna Cherevach,1 Tracey Chillingworth,1 Carol Churcher,1 Ann Cronin,1 Linda Dowd,1 Theresa Feltwell,1 Nancy Hamlin,1 Simon Holroyd,1 Kay Jagels,1 Sharon Moule,1 Karen Mungall,1 Michael A. Quail,1 Claire Price,1 Ester Rabbinowitsch,1 Sarah Sharp,1 Jason Skelton,1 Sally Whitehead,1 Bart G. Barrell,1 Michael Kehoe,2 and Julian Parkhill1

The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom,1 Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom2

Received 4 August 2006/ Accepted 19 September 2006

Comparisons of the 1.84-Mb genome of serotype M5 Streptococcus pyogenes strain Manfredo with previously sequenced genomes emphasized the role of prophages in diversification of S. pyogenes and the close relationship between strain Manfredo and MGAS8232, another acute rheumatic fever-associated strain.

* Corresponding author. Mailing address: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SA, United Kingdom. Phone: 44 (0)1223 494761. Fax: 44 (0)1223 494919. E-mail: mh3{at}sanger.ac.uk.

{triangledown} Published ahead of print on 29 September 2006.

Journal of Bacteriology, February 2007, p. 1473-1477, Vol. 189, No. 4
0021-9193/07/$08.00+0     doi:10.1128/JB.01227-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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