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Evidence that RpoS (^S) in Borrelia burgdorferi Is Controlled Directly by RpoN (⁵⁴/^N)

Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390,¹ Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202²

Received 25 October 2006/ Accepted 28 November 2006

The alternative sigma factor (RpoN-RpoS) pathway controls the expression of key virulence factors in Borrelia burgdorferi. However, evidence to support whether RpoN controls rpoS directly or, perhaps, indirectly via a transactivator has been lacking. Herein we provide biochemical and genetic evidence that RpoN directly controls rpoS in B. burgdorferi.

Published ahead of print on 8 December 2006.

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