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Journal of Bacteriology, March 2007, p. 2155-2159, Vol. 189, No. 5
0021-9193/07/$08.00+0     doi:10.1128/JB.01708-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Arylamine N-Acetyltransferase Responsible for Acetylation of 2-Aminophenols in Streptomyces griseus{triangledown} ,{dagger}

Hirokazu Suzuki, Yasuo Ohnishi, and Sueharu Horinouchi*

Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

Received 6 November 2006/ Accepted 29 November 2006

An arylamine N-acetyltransferase (NAT) responsible for the N acetylation of exogenous 3-amino-4-hydroxybenzoic acid in Streptomyces griseus was identified and characterized. This enzyme was distinct from other eukaryotic and bacterial NATs in that it acetylated various 2-aminophenol derivatives more effectively than it acetylated 5-aminosalicylic acid, and thus it may be involved in the metabolism of xenobiotic compounds.

* Corresponding author. Mailing address: Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan. Phone: 81 3 5841 5123. Fax: 81 3 5841 8021. E-mail: asuhori{at}mail.ecc.u-tokyo.ac.jp.

{triangledown} Published ahead of print on 8 December 2006.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, March 2007, p. 2155-2159, Vol. 189, No. 5
0021-9193/07/$08.00+0     doi:10.1128/JB.01708-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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