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Journal of Bacteriology, March 2007, p. 2176-2180, Vol. 189, No. 5
0021-9193/07/$08.00+0     doi:10.1128/JB.01611-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Number of G Residues in the Bacillus subtilis pyrG Initially Transcribed Region Governs Reiterative Transcription-Mediated Regulation{triangledown}

Alexander K. W. Elsholz,{dagger} Casper Møller Jørgensen, and Robert L. Switzer*

Department of Biochemistry, University of Illinois, Urbana, Illinois 61801

Received 16 October 2006/ Accepted 1 December 2006

Derepression of pyrG expression in Bacillus subtilis involves CTP-sensitive reiterative transcription, which introduces up to 11 extra G residues at the 5' ends of pyrG transcripts. Insertion of three or more additional Gs at the 5' end of the pyrG initially transcribed region abolished reiterative transcription and caused constitutive expression.

* Corresponding author. Mailing address: Department of Biochemistry, University of Illinois, 600 South Mathews, Urbana, IL 61801. Phone: (217) 333-3940. Fax: (217) 244-5858. E-mail: rswitzer{at}uiuc.edu.

{triangledown} Published ahead of print on 8 December 2006.

{dagger} Present address: Institute for Microbiology, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Strasse 15, D-17487 Greifswald, Germany.

Journal of Bacteriology, March 2007, p. 2176-2180, Vol. 189, No. 5
0021-9193/07/$08.00+0     doi:10.1128/JB.01611-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Turnbough, C. L. Jr., Switzer, R. L. (2008). Regulation of Pyrimidine Biosynthetic Gene Expression in Bacteria: Repression without Repressors. Microbiol. Mol. Biol. Rev. 72: 266-300 [Abstract] [Full Text]  


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