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Journal of Bacteriology, March 2007, p. 2417-2425, Vol. 189, No. 6
0021-9193/07/$08.00+0     doi:10.1128/JB.01277-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

CadC Has a Global Translational Effect during Acid Adaptation in Salmonella enterica Serovar Typhimurium{triangledown}

Yong Heon Lee,1 Bae Hoon Kim,1 Ji Hye Kim,1 Won Suck Yoon,1 Seong Ho Bang,2 and Yong Keun Park1*

School of Life Sciences and Biotechnology, Korea University, Seoul 136-701,1 Department of Biology, Hanseo University, Seosan 356-706, Korea2

Received 13 August 2006/ Accepted 17 December 2006

In Salmonella enterica serovar Typhimurium, the membrane-localized CadC is a transcriptional activator of the cadBA operon, which contributes to the acid tolerance response. Unlike in Escherichia coli, in which transcription of cadC is constitutive, in S. enterica serovar Typhimurium cadC expression is induced by low pH and lysine. Inactivation of cadC suppresses the acid-sensitive phenotype of a cadA mutation, suggesting the existence of other CadC-dependent genes in addition to the cadBA operon. Using a proteomic approach, we identified 8 of the putative CadC-induced proteins and 15 of the putative CadC-repressed proteins. The former include porin proteins OmpC and OmpF. The latter include proteins involved in glycolysis, energy production, and stress tolerance. To better understand the altered levels of OmpC and OmpF, we compared expression of ompR in S. enterica serovar Typhimurium wild-type and cadC mutant strains and determined that CadC exerted a negative influence on ompR transcription. Taken together, our findings strongly suggest that CadC may be a global regulator involved in the OmpR regulatory system during acid adaptation.

* Corresponding author. Mailing address: School of Life Sciences and Biotechnology, Korea University, Seoul 136-701, Korea. Phone: 82-2-3290-3422. Fax: 82-2-927-9028. E-mail: ykpark{at}korea.ac.kr.

{triangledown} Published ahead of print on 5 January 2007.

Journal of Bacteriology, March 2007, p. 2417-2425, Vol. 189, No. 6
0021-9193/07/$08.00+0     doi:10.1128/JB.01277-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hu, Y., Lu, P., Wang, Y., Ding, L., Atkinson, S., Chen, S. (2009). OmpR positively regulates urease expression to enhance acid survival of Yersinia pseudotuberculosis. Microbiology 155: 2522-2531 [Abstract] [Full Text]  
  • Lee, Y. H., Kim, J. H., Bang, I. S., Park, Y. K. (2008). The Membrane-Bound Transcriptional Regulator CadC Is Activated by Proteolytic Cleavage in Response to Acid Stress. J. Bacteriol. 190: 5120-5126 [Abstract] [Full Text]  


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