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Journal of Bacteriology, March 2007, p. 2553-2557, Vol. 189, No. 6
0021-9193/07/$08.00+0 doi:10.1128/JB.01635-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 3-1, 7-Chome, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Received 20 October 2006/ Accepted 19 December 2006
Wild-type Staphylococcus aureus rapidly expands on the surface of soft agar plates. The rates of expansion and the shapes of the resultant giant colonies were distinct for different strains of laboratory stocks and clinical isolates. The colony spreading abilities did not correlate with the biofilm-forming abilities in these strains. Insertional disruption of the dltABCD operon, which functions at the step of D-alanine addition to teichoic acids, and of the tagO gene, which is responsible for the synthesis of wall teichoic acids, decreased the colony spreading ability. The results indicate that wall teichoic acids and D-alanylation of teichoic acids are required for colony spreading.
Published ahead of print on 28 December 2006.
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