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Journal of Bacteriology, March 2007, p. 2558-2560, Vol. 189, No. 6
0021-9193/07/$08.00+0     doi:10.1128/JB.01358-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Aeromonas salmonicida Toxin AexT Has a Rho Family GTPase-Activating Protein Domain{triangledown}

Yael Litvak and Zvi Selinger*

Department of Biological Chemistry and the Kuhne Minerva Center, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

Received 27 August 2006/ Accepted 5 January 2007

The N terminus of the Aeromonas salmonicida ADP-ribosylating toxin AexT displays in vitro GTPase-activating protein (GAP) activity for Rac1, CDC42, and RhoA. HeLa cells transfected with the AexT N terminus exhibit rounding and actin disordering. We propose that the Aeromonas salmonicida AexT toxin is a novel member of the growing family of bacterial RhoGAPs.

* Corresponding author. Mailing address: Institute of Life Sciences, Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 Israel. Phone: 972-2-6585419. Fax: 972-2-6527427. E-mail: selinger{at}vms.huji.ac.il.

{triangledown} Published ahead of print on 19 January 2007.

Journal of Bacteriology, March 2007, p. 2558-2560, Vol. 189, No. 6
0021-9193/07/$08.00+0     doi:10.1128/JB.01358-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Fehr, D., Burr, S. E., Gibert, M., d'Alayer, J., Frey, J., Popoff, M. R. (2007). Aeromonas Exoenzyme T of Aeromonas salmonicida Is a Bifunctional Protein That Targets the Host Cytoskeleton. J. Biol. Chem. 282: 28843-28852 [Abstract] [Full Text]  


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