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Enhanced Post-Stationary-Phase Survival of a Clinical Thymidine-Dependent Small-Colony Variant of Staphylococcus aureus Results from Lack of a Functional Tricarboxylic Acid Cycle

Institute of Medical Microbiology and Hygiene, Institutes of Infectious Disease Medicine, University of Saarland, Homburg/Saar, Germany,¹ Departments of Medicine and of Medical Microbiology and Immunology, University of Wisconsin Medical School, Madison, Wisconsin,² Institute of Medical Microbiology, University Hospital of Münster, Münster, Germany³

Received 12 September 2006/ Accepted 15 January 2007

The mechanisms underlying the persistence of the Staphylococcus aureus small-colony variant (SCV) are not fully elucidated. In this study, clinical thymidine-dependent SCVs displayed altered expression of citB, clpC, and arcA genes, reduced acetate catabolization, and enhanced survival. These results implicate the importance of changes in tricarboxylic acid cycle and acetic acid metabolism in SCV survival and persistence.

Published ahead of print on 26 January 2007.

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