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Journal of Bacteriology, May 2007, p. 3669-3673, Vol. 189, No. 9
0021-9193/07/$08.00+0     doi:10.1128/JB.00002-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Repression of Intracellular Virulence Factors in Salmonella by the Hha and YdgT Nucleoid-Associated Proteins{triangledown}

Umaporn Silphaduang,1,2,3 Mariola Mascarenhas,2 Mohamed Karmali,2,3 and Brian K. Coombes1,2*

Department of Biochemistry and Biomedical Sciences and Antimicrobial Research Centre, McMaster University, Hamilton, ON, Canada,1 Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Guelph, ON, Canada,2 Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada3

Received 1 January 2007/ Accepted 9 February 2007

The Hha/YmoA family of nucleoid-associated proteins is involved in gene regulation in enterobacteria. In Salmonella enterica serovar Typhimurium, virulence genes required for intracellular growth are induced following host cell invasion but the proteins responsible for repressing these genes prior to host cell entry have not been fully identified. We demonstrate here that Hha is the major repressor responsible for silencing virulence genes carried in Salmonella pathogenicity island 2 prior to bacteria sensing an intracellular environmental cue.

* Corresponding author. Mailing address: Department of Biochemistry and Biomedical Sciences, McMaster University, Health Sciences Centre, Room 4H17, 1200 Main St. West, Hamilton, Ontario L8N 3Z5, Canada. Phone: 905-525-9140, ext. 22159. Fax: 905-522-9033. E-mail: coombes{at}mcmaster.ca

{triangledown} Published ahead of print on 16 February 2007.

Journal of Bacteriology, May 2007, p. 3669-3673, Vol. 189, No. 9
0021-9193/07/$08.00+0     doi:10.1128/JB.00002-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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