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Evidence that AphB, Essential for the Virulence of Vibrio vulnificus, Is a Global Regulator ^,

National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, South Korea

Received 12 January 2008/ Accepted 4 March 2008

The Vibrio vulnificus aphB mutant was significantly less virulent than the wild type and was impaired in motility and adherence to host cells. Microarray analysis revealed that AphB of V. vulnificus (AphB_Vv) influences the expression of over 10% of the V. vulnificus genome. The combined results indicated that AphB_Vv is a global regulator contributing to the pathogenesis of V. vulnificus.

Published ahead of print on 14 March 2008.

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