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Journal of Bacteriology, June 2008, p. 4091-4094, Vol. 190, No. 11
0021-9193/08/$08.00+0     doi:10.1128/JB.00233-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Methanothermobacter thermautotrophicus Cdc6-2 Protein, the Putative Helicase Loader, Dissociates the Minichromosome Maintenance Helicase

Jae-Ho Shin,^1, Gun Young Heo,^2, and Zvi Kelman^2*

School of Applied Biosciences, Kyungpook National University, Daegu 702-701, Republic of Korea,¹ University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, Maryland 20850²

Received 15 February 2008/ Accepted 24 March 2008

The Cdc6-1 and -2 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind the minichromosome maintenance (MCM) helicase. It is shown here that Cdc6-2 protein dissociates the MCM complex. This observation supports the hypothesis that the Cdc6-2 protein functions as a helicase loader.

Published ahead of print on 4 April 2008.

These authors contributed equally to the study.