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Journal of Bacteriology, June 2008, p. 4100-4105, Vol. 190, No. 11
0021-9193/08/$08.00+0     doi:10.1128/JB.01728-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Sodium Chloride Affects Helicobacter pylori Growth and Gene Expression{triangledown}

Hanan Gancz, Kathleen R. Jones, and D. Scott Merrell*

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, Maryland 20814

Received 29 October 2007/ Accepted 17 March 2008

Epidemiological evidence links high-salt diets and Helicobacter pylori infection with increased risk of developing gastric maladies. The mechanism by which elevated sodium chloride content causes these manifestations is unclear. Here we characterize the response of H. pylori to temporal changes in sodium chloride concentration and show that growth, cell morphology, survival, and virulence factor expression are all altered by increased salt concentration.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814. Phone: (301) 295-1584. Fax: (301) 295-3773. E-mail: dmerrell{at}usuhs.mil

{triangledown} Published ahead of print on 28 March 2008.

Journal of Bacteriology, June 2008, p. 4100-4105, Vol. 190, No. 11
0021-9193/08/$08.00+0     doi:10.1128/JB.01728-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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