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Journal of Bacteriology, July 2008, p. 4772-4776, Vol. 190, No. 13
0021-9193/08/$08.00+0     doi:10.1128/JB.00015-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Two-Component System CesRK Controls the Transcriptional Induction of Cell Envelope-Related Genes in Listeria monocytogenes in Response to Cell Wall-Acting Antibiotics ^,

Sanne Gottschalk,¹ Iver Bygebjerg-Hove,¹ Mette Bonde,¹ Pia Kiil Nielsen,¹ Thanh Ha Nguyen,¹ Anne Gravesen,^2, and Birgitte H. Kallipolitis^1*

Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark,¹ Department of Food Science, University of Copenhagen, Rolighedvej 30, 1958 Frederiksberg C, Denmark²

Received 4 January 2008/ Accepted 24 April 2008

The two-component system CesRK of Listeria monocytogenes responds to cell wall-acting antibiotics. We show here that CesRK controls the transcription of several cell envelope-related genes. The CesRK-dependent induction of these genes may be viewed as an attempt by L. monocytogenes to protect itself against the damaging effects of cell wall-acting antibiotics.

Published ahead of print on 2 May 2008.

Supplemental material for this article may be found at http://jb.asm.org/.

Present address: Danisco A/S, Edwin Rahrs Vej 38, 8220 Brabrand, Denmark.