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Journal of Bacteriology, August 2008, p. 5526-5530, Vol. 190, No. 15
0021-9193/08/$08.00+0     doi:10.1128/JB.00558-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Autoregulation of AbsB (RNase III) Expression in Streptomyces coelicolor by Endoribonucleolytic Cleavage of absB Operon Transcripts{triangledown}

Weijing Xu, Jianqiang Huang, and Stanley N. Cohen*

Department of Genetics, MC5120, Stanford University School of Medicine, Stanford, California 94305

Received 22 April 2008/ Accepted 25 May 2008

The Streptomyces coelicolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibiotic biosynthesis. Here we report that AbsB controls its own expression by sequentially and site specifically cleaving stem-loop segments of its polycistronic transcript. Our results demonstrate a ribonucleolytic regulatory role for AbsB in vivo.

* Corresponding author. Mailing address: Department of Genetics, Stanford University, Stanford, CA 94305. Phone: (650) 723-5315. Fax: (650) 725-1536. E-mail: sncohen{at}stanford.edu

{triangledown} Published ahead of print on 6 June 2008.

Journal of Bacteriology, August 2008, p. 5526-5530, Vol. 190, No. 15
0021-9193/08/$08.00+0     doi:10.1128/JB.00558-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Kim, K.-s., Manasherob, R., Cohen, S. N. (2008). YmdB: a stress-responsive ribonuclease-binding regulator of E. coli RNase III activity. Genes Dev. 22: 3497-3508 [Abstract] [Full Text]  
  • Gravenbeek, M. L., Jones, G. H. (2008). The endonuclease activity of RNase III is required for the regulation of antibiotic production by Streptomyces coelicolor. Microbiology 154: 3547-3555 [Abstract] [Full Text]  


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