JB
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
JB.00558-08v1
190/15/5526    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Xu, W.
Right arrow Articles by Cohen, S. N.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xu, W.
Right arrow Articles by Cohen, S. N.

 Previous Article  |  Next Article 

Journal of Bacteriology, August 2008, p. 5526-5530, Vol. 190, No. 15
0021-9193/08/$08.00+0     doi:10.1128/JB.00558-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Autoregulation of AbsB (RNase III) Expression in Streptomyces coelicolor by Endoribonucleolytic Cleavage of absB Operon Transcripts{triangledown}

Weijing Xu, Jianqiang Huang, and Stanley N. Cohen*

Department of Genetics, MC5120, Stanford University School of Medicine, Stanford, California 94305

Received 22 April 2008/ Accepted 25 May 2008

The Streptomyces coelicolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibiotic biosynthesis. Here we report that AbsB controls its own expression by sequentially and site specifically cleaving stem-loop segments of its polycistronic transcript. Our results demonstrate a ribonucleolytic regulatory role for AbsB in vivo.

* Corresponding author. Mailing address: Department of Genetics, Stanford University, Stanford, CA 94305. Phone: (650) 723-5315. Fax: (650) 725-1536. E-mail: sncohen{at}stanford.edu

{triangledown} Published ahead of print on 6 June 2008.

Journal of Bacteriology, August 2008, p. 5526-5530, Vol. 190, No. 15
0021-9193/08/$08.00+0     doi:10.1128/JB.00558-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Appl. Environ. Microbiol. Infect. Immun. Eukaryot. Cell
Mol. Cell. Biol. J. Virol. Microbiol. Mol. Biol. Rev.
ALL ASM JOURNALS

Copyright © 2008 by the American Society for Microbiology. All rights reserved.