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Journal of Bacteriology, September 2008, p. 6253-6257, Vol. 190, No. 18
0021-9193/08/$08.00+0     doi:10.1128/JB.00737-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Characterization of an Inducible, Antibiotic-Resistant Aminoacyl-tRNA Synthetase Gene in Streptomyces coelicolor{triangledown} ,{dagger}

James J. Vecchione and Jason K. Sello*

Department of Chemistry, Brown University, 324 Brook Street, Providence, Rhode Island 02912

Received 23 May 2008/ Accepted 1 July 2008

Streptomyces coelicolor has two genes encoding tryptophanyl-tRNA synthetases, one of which (trpRS1) is resistant to and transcriptionally activated by indolmycin. We found that this gene also confers resistance to chuangxinmycin (another antibiotic that inhibits bacterial tryptophanyl-tRNA synthetases) and that its transcription is not absolutely dependent on either antibiotic.

* Corresponding author. Mailing address: Department of Chemistry, Brown University, 324 Brook Street, Providence, Rhode Island 02912. Phone: (401) 863-1194. Fax: (401) 863-9046. E-mail: Jason_sello{at}brown.edu

{triangledown} Published ahead of print on 11 July 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, September 2008, p. 6253-6257, Vol. 190, No. 18
0021-9193/08/$08.00+0     doi:10.1128/JB.00737-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vecchione, J. J., Alexander, B. Jr., Sello, J. K. (2009). Two Distinct Major Facilitator Superfamily Drug Efflux Pumps Mediate Chloramphenicol Resistance in Streptomyces coelicolor. Antimicrob. Agents Chemother. 53: 4673-4677 [Abstract] [Full Text]  
  • Vecchione, J. J., Sello, J. K. (2009). A Novel Tryptophanyl-tRNA Synthetase Gene Confers High-Level Resistance to Indolmycin. Antimicrob. Agents Chemother. 53: 3972-3980 [Abstract] [Full Text]  


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