This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hirakawa, H.
Right arrow Articles by Yamaguchi, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hirakawa, H.
Right arrow Articles by Yamaguchi, A.

 Previous Article

Journal of Bacteriology, September 2008, p. 6276-6279, Vol. 190, No. 18
0021-9193/08/$08.00+0     doi:10.1128/JB.00190-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

AcrS/EnvR Represses Expression of the acrAB Multidrug Efflux Genes in Escherichia coli{triangledown}

Hidetada Hirakawa,1,{dagger} Asuka Takumi-Kobayashi,1,2 Ulrike Theisen,1,4 Takahiro Hirata,1,2,{ddagger} Kunihiko Nishino,1,2,3 and Akihito Yamaguchi1,2*

Department of Cell Membrane Biology, Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan,1 Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan,2 PRESTO, Japan Science and Technology Corporation, Tokyo, Japan,3 School of Biosciences, University of Exeter, Exeter, United Kingdom4

Received 7 February 2008/ Accepted 12 June 2008

The acrS regulatory gene is located upstream of the acrEF multidrug efflux system genes. However, the roles of AcrS in regulation of drug efflux pumps have not been clearly understood. Here we show that AcrS represses other multidrug efflux genes, acrAB, which encode a major efflux system in Escherichia coli.

* Corresponding author. Mailing address: Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan. Phone: 81-6-6879-8545. Fax: 81-6-6879-8549. E-mail: akihito{at}sanken.osaka-u.ac.jp

{triangledown} Published ahead of print on 20 June 2008.

{dagger} Present address: Department of Microbiology, University of Washington, Seattle, WA 98105-7242.

{ddagger} Present address: Pharmaceutical Department, Josai International University, Togane, Chiba 283-8555, Japan.

Journal of Bacteriology, September 2008, p. 6276-6279, Vol. 190, No. 18
0021-9193/08/$08.00+0     doi:10.1128/JB.00190-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»