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Journal of Bacteriology, October 2008, p. 6524-6529, Vol. 190, No. 19
0021-9193/08/$08.00+0     doi:10.1128/JB.00765-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Role of the Campylobacter jejuni Cj1461 DNA Methyltransferase in Regulating Virulence Characteristics{triangledown} ,{dagger}

Joo-Sung Kim,1 Jiaqi Li,1 If H. A. Barnes,1 David A. Baltzegar,1 Mohanasundari Pajaniappan,1 Thomas W. Cullen,1 M. Stephen Trent,1 Christopher M. Burns,2 and Stuart A. Thompson1*

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia 30912,1 College of Biomedical Science, Florida Atlantic University, Boca Raton, Florida 334312

Received 29 May 2008/ Accepted 21 July 2008

Mutation of the cj1461 predicted methyltransferase gene reduced the motility of Campylobacter jejuni 81-176. Electron microscopy revealed that the mutant strain had flagella but with aberrant structure. The {Delta}cj1461 mutant was sevenfold more adherent to but 50-fold less invasive of INT-407 human epithelial cells than the wild type.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912. Phone: (706) 721-7277. Fax: (706) 721-6608. E-mail: stthomps{at}mcg.edu

{triangledown} Published ahead of print on 8 August 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, October 2008, p. 6524-6529, Vol. 190, No. 19
0021-9193/08/$08.00+0     doi:10.1128/JB.00765-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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