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Journal of Bacteriology, October 2008, p. 6530-6533, Vol. 190, No. 19
0021-9193/08/$08.00+0     doi:10.1128/JB.00482-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Regulation of the Intercellular Adhesin Locus Regulator (icaR) by SarA, {sigma}B, and IcaR in Staphylococcus aureus{triangledown}

Nuno Cerca, Jamie L. Brooks, and Kimberly K. Jefferson*

Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond Virginia 23928

Received 8 April 2008/ Accepted 15 July 2008

The staphylococcal accessory regulator SarA and the alternative sigma factor {sigma}B have been previously identified as positive regulators, and IcaR as a negative regulator, of icaADBC expression. Here, we show that in Staphylococcus aureus SarA and {sigma}B are also required for icaR expression and that IcaR does not have a significant effect on its own expression.

* Corresponding author. Mailing address: Virginia Commonwealth University, Department of Microbiology and Immunology, P.O. Box 980678, Richmond, VA 23928. Phone: (804) 828-9699. Fax: (804) 828-9946. E-mail: kkjefferson{at}vcu.edu

{triangledown} Published ahead of print on 25 July 2008.

Journal of Bacteriology, October 2008, p. 6530-6533, Vol. 190, No. 19
0021-9193/08/$08.00+0     doi:10.1128/JB.00482-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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