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Journal of Bacteriology, January 2008, p. 755-758, Vol. 190, No. 2
0021-9193/08/$08.00+0     doi:10.1128/JB.01335-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

DNA Polymerase I Is Not Required for Replication of Linear Chromosomes in Streptomyces{triangledown} ,{dagger}

Tzu-Wen Huang and Carton W. Chen*

Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Shih-Pai, Taipei 112, Taiwan

Received 17 August 2007/ Accepted 1 November 2007

Both polA (encoding DNA polymerase I; Pol I) and a paralog were deleted from Streptomyces strains. Despite the UV sensitivity and slow growth caused by the {Delta}polA mutation, the double mutant was viable. Thus, in contrast to a previous postulate, Pol I and its paralog are not essential for replication of Streptomyces chromosomes.

* Corresponding author. Mailing address: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Shih-Pai, Taipei 112, Taiwan. Phone: 886-2-2826-7040. Fax: 886-2-2826-4930. E-mail: cwchen{at}ym.edu.tw

{triangledown} Published ahead of print on 9 November 2007.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, January 2008, p. 755-758, Vol. 190, No. 2
0021-9193/08/$08.00+0     doi:10.1128/JB.01335-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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