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Journal of Bacteriology, January 2008, p. 759-763, Vol. 190, No. 2
0021-9193/08/$08.00+0     doi:10.1128/JB.01151-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

LmrR Is a Transcriptional Repressor of Expression of the Multidrug ABC Transporter LmrCD in Lactococcus lactis{triangledown}

Herfita Agustiandari,1 Jacek Lubelski,2 H. Bart van den Berg van Saparoea,1 Oscar P. Kuipers,2 and Arnold J. M. Driessen1*

Department of Molecular Microbiology,1 Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, NL-9751 NN Haren, The Netherlands2

Received 20 July 2007/ Accepted 29 October 2007

LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a {Delta}lmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression.

* Corresponding author. Mailing address: Department of Microbiology, University of Groningen, Kerklaan 30, 9751 NN, Haren, The Netherlands. Phone: 31-50-3632164. Fax: 31-50-3632154. E-mail: a.j.m.driessen{at}rug.nl

{triangledown} Published ahead of print on 9 November 2007.

Journal of Bacteriology, January 2008, p. 759-763, Vol. 190, No. 2
0021-9193/08/$08.00+0     doi:10.1128/JB.01151-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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