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Journal of Bacteriology, January 2008, p. 769-771, Vol. 190, No. 2
0021-9193/08/$08.00+0     doi:10.1128/JB.01253-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

LuxS Affects Flagellar Phase Variation Independently of Quorum Sensing in Salmonella enterica Serovar Typhimurium{triangledown}

M. H. Karavolos,1 D. M. Bulmer,1,{dagger} K. Winzer,2,{dagger} M. Wilson,1 P. Mastroeni,3 P. Williams,4 and C. M. A. Khan1*

Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle NE2 4HH,1 Department of Biological Sciences, Lancaster University, Lancaster LA1 4YQ,2 Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES,3 Institute of Infection Immunity and Inflammation, Centre for Biomolecular Sciences, University Park, University of Nottingham, Nottingham NG7 RD, United Kingdom4

Received 3 August 2007/ Accepted 19 October 2007

LuxS catalyzes the synthesis of the quorum-sensing signaling molecule autoinducer 2. We show that in Salmonella enterica serovar Typhimurium, deletion of the luxS gene polarizes flagellar phase variation toward the more immunogenic phase 1 flagellin. This phenotype is complementable by luxS in trans but is independent of quorum-sensing signals.

* Corresponding author. Mailing address: Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom. Phone: 44-191 2227066. Fax: 44-191 2227424. E-mail: anjam.khan{at}ncl.ac.uk

{triangledown} Published ahead of print on 16 November 2007.

{dagger} These authors have contributed equally to the work.

Journal of Bacteriology, January 2008, p. 769-771, Vol. 190, No. 2
0021-9193/08/$08.00+0     doi:10.1128/JB.01253-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Perrett, C. A., Karavolos, M. H., Humphrey, S., Mastroeni, P., Martinez-Argudo, I., Spencer, H., Bulmer, D., Winzer, K., McGhie, E., Koronakis, V., Williams, P., Khan, C. M. A., Jepson, M. A. (2009). LuxS-Based Quorum Sensing Does Not Affect the Ability of Salmonella enterica Serovar Typhimurium To Express the SPI-1 Type 3 Secretion System, Induce Membrane Ruffles, or Invade Epithelial Cells. J. Bacteriol. 191: 7253-7259 [Abstract] [Full Text]  
  • Atkinson, S., Williams, P. (2009). Quorum sensing and social networking in the microbial world. J R Soc Interface 6: 959-978 [Abstract] [Full Text]  


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