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Journal of Bacteriology, October 2008, p. 6909-6912, Vol. 190, No. 20
0021-9193/08/$08.00+0     doi:10.1128/JB.00451-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Trade-Off between Iron Uptake and Protection against Oxidative Stress: Deletion of cueO Promotes Uropathogenic Escherichia coli Virulence in a Mouse Model of Urinary Tract Infection{triangledown}

Jai J. Tree,1 Glen C. Ulett,1 Cheryl-Lynn Y. Ong,1 Darren J. Trott,2 Alastair G. McEwan,1 and Mark A. Schembri1*

School of Molecular and Microbial Sciences,1 School of Veterinary Science, University of Queensland, Brisbane, Queensland 4072, Australia2

Received 2 April 2008/ Accepted 12 August 2008

The periplasmic multicopper oxidase (CueO) is involved in copper homeostasis and protection against oxidative stress. Here, we show that the deletion of cueO in uropathogenic Escherichia coli increases its colonization of the urinary tract despite its increased sensitivity to hydrogen peroxide. The cueO deletion mutant accumulated iron with increased efficiency compared to its parent strain; this may account for its advantage in the iron-limited environment of the urinary tract.

* Corresponding author. Mailing address: School of Molecular and Microbial Sciences, University of Queensland, Brisbane 4072, Australia. Phone: 61 7 3365 3306. Fax: 61 7 3365 4699. E-mail: m.schembri{at}uq.edu.au

{triangledown} Published ahead of print on 22 August 2008.

Journal of Bacteriology, October 2008, p. 6909-6912, Vol. 190, No. 20
0021-9193/08/$08.00+0     doi:10.1128/JB.00451-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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