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Journal of Bacteriology, October 2008, p. 6927-6930, Vol. 190, No. 20
0021-9193/08/$08.00+0     doi:10.1128/JB.00801-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Paerucumarin, a New Metabolite Produced by the pvc Gene Cluster from Pseudomonas aeruginosa{triangledown} ,{dagger}

Michael F. Clarke-Pearson and Sean F. Brady*

Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10065

Received 7 June 2008/ Accepted 28 July 2008

The pvc gene cluster from Pseudomonas aeruginosa has been linked to the biosynthesis of both the pyoverdine chromophore and pseudoverdine. Our reinvestigation of the role this gene cluster plays in P. aeruginosa secondary metabolite biosynthesis shows that its major product is actually paerucumarin, a novel isonitrile functionalized cumarin.

* Corresponding author. Mailing address: Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, NY 10065. Phone: (212) 327-8280. Fax: (212) 327-8281. E-mail: sbrady{at}rockefeller.edu

{triangledown} Published ahead of print on 8 August 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, October 2008, p. 6927-6930, Vol. 190, No. 20
0021-9193/08/$08.00+0     doi:10.1128/JB.00801-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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