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Journal of Bacteriology, November 2008, p. 7291-7297, Vol. 190, No. 21
0021-9193/08/$08.00+0     doi:10.1128/JB.00739-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Roles and Interactions of Burkholderia pseudomallei BpsIR Quorum-Sensing System Determinants{triangledown}

Pattarachai Kiratisin* and Sittinee Sanmee

Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

Received 24 May 2008/ Accepted 19 August 2008

The Burkholderia pseudomallei quorum-sensing system (QSS), designated BpsIR, is encoded by five bpsR genes and three bpsI genes. This study investigated the roles and interactions of the QSS determinants in terms of gene regulation and protein interaction. We report two novel findings, that BpsR can function as an activator and a repressor for bpsI expression and that BpsR may form homodimers and heterodimers.

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Prannok Rd., Bangkok-Noi, Bangkok 10700, Thailand. Phone: 66-2-419-7058. Fax: 66-2-411-3106. E-mail: sipkr{at}mahidol.ac.th

{triangledown} Published ahead of print on 29 August 2008.

Journal of Bacteriology, November 2008, p. 7291-7297, Vol. 190, No. 21
0021-9193/08/$08.00+0     doi:10.1128/JB.00739-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Malott, R. J., O'Grady, E. P., Toller, J., Inhulsen, S., Eberl, L., Sokol, P. A. (2009). A Burkholderia cenocepacia Orphan LuxR Homolog Is Involved in Quorum-Sensing Regulation. J. Bacteriol. 191: 2447-2460 [Abstract] [Full Text]  


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