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Journal of Bacteriology, February 2008, p. 1128-1133, Vol. 190, No. 3
0021-9193/08/$08.00+0     doi:10.1128/JB.00511-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Role of Stress Response Sigma Factor SigG in Mycobacterium tuberculosis{triangledown} ,{dagger}

Jong-Hee Lee, Deborah E. Geiman, and William R. Bishai*

Department of Medicine, Johns Hopkins School of Medicine, CRB2 Room 1.08, 1550 Orleans Street, Baltimore, Maryland 21231-1044

Received 3 April 2007/ Accepted 7 November 2007

The sigG gene of Mycobacterium tuberculosis was disrupted by homologous recombination, and the genes regulated by SigG were examined by real-time reverse-transcription PCR and microarray studies. The SigG consensus promoter recognition sequence was identified as GCGNGT-N15-18-CGANCA. A {Delta}sigG mutant was found to be more resistant to mitomycin C treatment than the wild-type strain, indicating that it may be involved in the SOS response in M. tuberculosis.

* Corresponding author. Mailing address: Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, CRB2, Room 1.08, 1550 Orleans Street, Baltimore, MD 21231-1044. Phone: (410) 955-3507. Fax: (410) 614-8173. E-mail: wbishai{at}jhmi.edu

{triangledown} Published ahead of print on 26 November 2007.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, February 2008, p. 1128-1133, Vol. 190, No. 3
0021-9193/08/$08.00+0     doi:10.1128/JB.00511-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Wu, S., Barnes, P. F., Samten, B., Pang, X., Rodrigue, S., Ghanny, S., Soteropoulos, P., Gaudreau, L., Howard, S. T. (2009). Activation of the eis gene in a W-Beijing strain of Mycobacterium tuberculosis correlates with increased SigA levels and enhanced intracellular growth. Microbiology 155: 1272-1281 [Abstract] [Full Text]  


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