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Modulation of Horizontally Acquired Genes by the Hha-YdgT Proteins in Salmonella enterica Serovar Typhimurium ^,

Departament de Microbiologia, Universitat de Barcelona, Avda. Diagonal 645, 08028 Barcelona, Spain,¹ Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología (CSIC), Darwin 3, 28049 Madrid, Spain,² BioinfoGP, Centro Nacional de Biotecnología-CSIC, Madrid, Spain³

Received 27 July 2007/ Accepted 13 November 2007

We describe a transcriptomic study of the effect of hha and ydgT mutations in Salmonella enterica serovar Typhimurium. A large number of genes showing altered expression are located in AT-rich horizontally acquired DNA sequences. Many of these genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS, our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when they silence these DNA regions.

Published ahead of print on 26 November 2007.

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