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Mutation at Different Sites in the Nostoc punctiforme cyaC Gene, Encoding the Multiple-Domain Enzyme Adenylate Cyclase, Results in Different Levels of Infection of the Host Plant Blasia pusilla

Karen E. Chapman, Paula S. Duggan, Natalie A. Billington née Joseph, and David G. Adams^*

Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom

Received 15 August 2007/ Accepted 11 December 2007

The filamentous cyanobacterium Nostoc punctiforme forms symbioses with plants. Disruption of the catalytic domain of the N. punctiforme adenylate cyclase (CyaC) significantly increased symbiotic competence, whereas reduced infectivity was observed in a mutant with a disruption close to the N terminus of CyaC. The total cellular cyclic AMP levels were significantly reduced in both mutants.

Published ahead of print on 21 December 2007.

Present address: Nspm Ag, Luzernerstrasse 36, CH-6045 Meggen, Switzerland.