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Journal of Bacteriology, March 2008, p. 2227-2230, Vol. 190, No. 6
0021-9193/08/$08.00+0     doi:10.1128/JB.01642-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Critical Role of a Single Position in the –35 Element for Promoter Recognition by Mycobacterium tuberculosis SigE and SigH{triangledown}

Taeksun Song,1 Seung-Eun Song,1 Sahadevan Raman,2 Mauricio Anaya,2 and Robert N. Husson2*

The Genome Research Center for Respiratory Pathogens, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea,1 Division of Infectious Diseases, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts2

Received 10 October 2007/ Accepted 31 December 2007

Mycobacterial SigE and SigH both initiate transcription from the sigB promoter, suggesting that they recognize similar sequences. Through mutational and primer extension analyses, we determined that SigE and SigH recognize nearly identical promoters, with differences at the 3' end of the –35 element distinguishing between SigE- and SigH-dependent promoters.

* Corresponding author. Mailing address: Division of Infectious Diseases, Children's Hospital Boston, 300 Longwood Ave., Boston, MA 02115. Phone: (617) 919-2900. Fax: (617) 730-0254. E-mail: robert.husson{at}childrens.harvard.edu

{triangledown} Published ahead of print on 11 January 2008.

Journal of Bacteriology, March 2008, p. 2227-2230, Vol. 190, No. 6
0021-9193/08/$08.00+0     doi:10.1128/JB.01642-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Mehra, S., Kaushal, D. (2009). Functional Genomics Reveals Extended Roles of the Mycobacterium tuberculosis Stress Response Factor {sigma}H. J. Bacteriol. 191: 3965-3980 [Abstract] [Full Text]  
  • Dona, V., Rodrigue, S., Dainese, E., Palu, G., Gaudreau, L., Manganelli, R., Provvedi, R. (2008). Evidence of Complex Transcriptional, Translational, and Posttranslational Regulation of the Extracytoplasmic Function Sigma Factor {sigma}E in Mycobacterium tuberculosis. J. Bacteriol. 190: 5963-5971 [Abstract] [Full Text]  


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