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Journal of Bacteriology, March 2008, p. 2239-2243, Vol. 190, No. 6
0021-9193/08/$08.00+0     doi:10.1128/JB.01826-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

SarA of Staphylococcus aureus Binds to the sarA Promoter To Regulate Gene Expression{triangledown}

Ambrose L. Cheung,1* Koren Nishina, and Adhar C. Manna2

Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire 03755,1 Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota 570692

Received 19 November 2007/ Accepted 24 December 2007

The 375-bp sarA open reading frame is driven by three promoters, P1, P3, and P2. Using gel shift and DNase I footprinting assays, we found that SarA binds to two 26-bp sequences and one 31-bp sequence within the P1 and P3 promoters, respectively. Together with the results of transcription analyses, our data indicate that SarA binds to its own promoter to down-regulate sarA expression.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Vail 210, Dartmouth Medical School, Hanover, NH 03766. Phone: (603) 650-1340. Fax: (603) 650-1362. E-mail: Ambrose.Cheung{at}Dartmouth.edu

{triangledown} Published ahead of print on 4 January 2008.

Journal of Bacteriology, March 2008, p. 2239-2243, Vol. 190, No. 6
0021-9193/08/$08.00+0     doi:10.1128/JB.01826-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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