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Lineage-Specific Amino Acid Substitutions in Region 2 of the RNA Polymerase Subunit Affect the Temperature of Promoter Opening ^,

Institute of Molecular Genetics, Kurchatov Sq. 2, Moscow 123182, Russia,¹ Public Health Research Institute, 225 Warren Street, Newark, New Jersey 07103²

Received 3 January 2008/ Accepted 5 February 2008

Highly conserved amino acid residues in region 2 of the RNA polymerase subunit are known to participate in promoter recognition and opening. We demonstrated that nonconserved residues in this region collectively determine lineage-specific differences in the temperature of promoter opening.

Published ahead of print on 15 February 2008.

Supplemental material for this article may be found at http://jb.asm.org/.