This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Runco, L. M.
Right arrow Articles by Thanassi, D. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Runco, L. M.
Right arrow Articles by Thanassi, D. G.

 Previous Article  |  Next Article 

Journal of Bacteriology, May 2008, p. 3381-3385, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.01840-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Biogenesis of the Fraction 1 Capsule and Analysis of the Ultrastructure of Yersinia pestis{triangledown}

Lisa M. Runco, Selina Myrczek,{dagger} James B. Bliska, and David G. Thanassi*

Center for Infectious Diseases, Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794-5120

Received 21 November 2007/ Accepted 19 February 2008

Analysis of a Yersinia pestis {Delta}caf1A mutant demonstrated that the Caf1A usher is required for the assembly and secretion of the fraction 1 capsule. The capsule assembled into thin fibrils and denser aggregates on the bacterial surface. Pilus-like fibers were also detected on the surface of Y. pestis. The capsule occasionally coated these fibers, suggesting how the capsule may cloak surface features to prevent host recognition.

* Corresponding author. Mailing address: 242 Center for Infectious Diseases, Stony Brook University, Stony Brook, NY 11794-5120. Phone: (631) 632-4549. Fax: (631) 632-4294. E-mail: David.Thanassi{at}stonybrook.edu

{triangledown} Published ahead of print on 29 February 2008.

{dagger} Present address: Institute of Clinical Microbiology, Immunology and Hygiene, University Hospital Erlangen, Wasserturmstr. 3-5, D-91054 Erlangen, Germany.

Journal of Bacteriology, May 2008, p. 3381-3385, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.01840-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Cornelius, C. A., Quenee, L. E., Elli, D., Ciletti, N. A., Schneewind, O. (2009). Yersinia pestis IS1541 Transposition Provides for Escape from Plague Immunity. Infect. Immun. 77: 1807-1816 [Abstract] [Full Text]  
  • Sebbane, F., Jarrett, C., Gardner, D., Long, D., Hinnebusch, B. J. (2009). The Yersinia pestis caf1M1A1 Fimbrial Capsule Operon Promotes Transmission by Flea Bite in a Mouse Model of Bubonic Plague. Infect. Immun. 77: 1222-1229 [Abstract] [Full Text]  
  • Ivanov, M. I., Noel, B. L., Rampersaud, R., Mena, P., Benach, J. L., Bliska, J. B. (2008). Vaccination of Mice with a Yop Translocon Complex Elicits Antibodies That Are Protective against Infection with F1- Yersinia pestis. Infect. Immun. 76: 5181-5190 [Abstract] [Full Text]  
  • Lilo, S., Zheng, Y., Bliska, J. B. (2008). Caspase-1 Activation in Macrophages Infected with Yersinia pestis KIM Requires the Type III Secretion System Effector YopJ. Infect. Immun. 76: 3911-3923 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»