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Identification of Novel Genes and Pathways Affecting Salmonella Type III Secretion System 1 Using a Contact-Dependent Hemolysis Assay

Terry R. Field, Abigail N. Layton,^* Jennie Bispham, Mark P. Stevens, and Edouard E. Galyov

Division of Microbiology, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom

Received 26 July 2007/ Accepted 17 February 2008

We screened 5,700 Salmonella enterica serovar Typhimurium mutants for defects in type III secretion system 1 (T3SS-1)-mediated contact-dependent hemolysis to identify novel genes and pathways affecting the activity of T3SS-1. Our data suggest that previously unrecognized factors such as type I fimbriae may modulate the expression, activity, or deployment of this key virulence factor.

Published ahead of print on 29 February 2008.

T.R.F. and A.N.L. contributed equally to this work.

Present address: Department of Infection, Immunity, and Inflammation, Maurice Shock Building, University of Leicester, P.O. Box 138, Leicester LE1 9HN, United Kingdom.