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Journal of Bacteriology, May 2008, p. 3399-3403, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.01674-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

SOS Induction by Stabilized Topoisomerase IA Cleavage Complex Occurs via the RecBCD Pathway{triangledown} ,{dagger}

Jeanette H. Sutherland, Bokun Cheng, I-Fen Liu, and Yuk-Ching Tse-Dinh*

Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595

Received 16 October 2007/ Accepted 16 February 2008

Accumulation of mutant topoisomerase I cleavage complex can lead to SOS induction and cell death in Escherichia coli. The single-stranded break associated with mutant topoisomerase I cleavage complex is converted to double-stranded break, which then is processed by the RecBCD pathway, followed by association of RecA with the single-stranded DNA.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, Basic Science Building, New York Medical College, Valhalla, NY 10595. Phone: (914) 594-4061. Fax: (914) 594-4058. E-mail: yuk-ching_tse-dinh{at}nymc.edu

{triangledown} Published ahead of print on 29 February 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, May 2008, p. 3399-3403, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.01674-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Tse-Dinh, Y.-C. (2009). Bacterial topoisomerase I as a target for discovery of antibacterial compounds. Nucleic Acids Res 37: 731-737 [Abstract] [Full Text]  
  • Sorokin, E. P., Cheng, B., Rathi, S., Aedo, S. J., Abrenica, M. V., Tse-Dinh, Y.-C. (2008). Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region. Nucleic Acids Res 36: 4788-4796 [Abstract] [Full Text]  


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