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SOS Induction by Stabilized Topoisomerase IA Cleavage Complex Occurs via the RecBCD Pathway ^,

Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595

Received 16 October 2007/ Accepted 16 February 2008

Accumulation of mutant topoisomerase I cleavage complex can lead to SOS induction and cell death in Escherichia coli. The single-stranded break associated with mutant topoisomerase I cleavage complex is converted to double-stranded break, which then is processed by the RecBCD pathway, followed by association of RecA with the single-stranded DNA.

Published ahead of print on 29 February 2008.

Supplemental material for this article may be found at http://jb.asm.org/.

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