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Journal of Bacteriology, May 2008, p. 3408-3410, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.00009-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

IS6110, a Mycobacterium tuberculosis Complex-Specific Insertion Sequence, Is Also Present in the Genome of Mycobacterium smegmatis, Suggestive of Lateral Gene Transfer among Mycobacterial Species{triangledown} ,{dagger}

Abbie Coros,1 Erin DeConno,1 and Keith M. Derbyshire1,2*

Division of Infectious Disease, Wadsworth Center, New York State Department of Health,1 Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York 12201-20022

Received 3 January 2008/ Accepted 26 February 2008

IS6110 is an insertion element found exclusively within the members of the Mycobacterium tuberculosis complex (MTBC), and because of this exclusivity, it has become an important diagnostic tool in the identification of MTBC species. The restriction of IS6110 to the MTBC is hypothesized to arise from the inability of these bacteria to exchange DNA. We have identified an IS6110-related element in a strain of Mycobacterium smegmatis. The presence of IS6110 indicates that lateral gene transfer has occurred among mycobacterial species, suggesting that the mycobacterial gene pool is larger than previously suspected.

* Corresponding author. Mailing address: David Axelrod Institute, NYS Department of Health, P.O. Box 22002, Albany, NY 12201-2002. Phone: (518) 473-6079. Fax: (518) 474-3181. E-mail: keith.derbyshire{at}wadsworth.org

{triangledown} Published ahead of print on 7 March 2008.

{dagger} Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, May 2008, p. 3408-3410, Vol. 190, No. 9
0021-9193/08/$08.00+0     doi:10.1128/JB.00009-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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