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Journal of Bacteriology, August 2009, p. 5013-5019, Vol. 191, No. 15
0021-9193/09/$08.00+0     doi:10.1128/JB.00473-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Intraspecies Signaling Involving the Diffusible Signal Factor BDSF (cis-2-Dodecenoic Acid) Influences Virulence in Burkholderia cenocepacia{triangledown} ,§

Robert P. Ryan,1 Yvonne McCarthy,1 Steven A. Watt,2 Karsten Niehaus,2 and J. Maxwell Dow1*

BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, University College Cork, Cork, Ireland,1 Department of Proteome and Metabolome Research, Faculty of Biology, Bielefeld University, P.O. Box 100131, D-33501 Bielefeld, Germany2

Received 7 April 2009/ Accepted 22 May 2009

Burkholderia cenocepacia produces a diffusible fatty acid signal molecule, cis-2-dodecenoic acid (BDSF), that has been implicated in interspecies and interkingdom communication. Here, we show that BDSF also acts as an intraspecies signal in B. cenocepacia to control factors contributing to virulence of this major opportunistic pathogen.

* Corresponding author. Mailing address: BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, University College Cork, Cork, Ireland. Phone: 353-21-4901316. Fax: 353-21-4275934. E-mail: m.dow{at}ucc.ie

{triangledown} Published ahead of print on 29 May 2009.

§ Supplemental material for this article may be found at http://jb.asm.org/.

Journal of Bacteriology, August 2009, p. 5013-5019, Vol. 191, No. 15
0021-9193/09/$08.00+0     doi:10.1128/JB.00473-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Deng, Y., Boon, C., Eberl, L., Zhang, L.-H. (2009). Differential Modulation of Burkholderia cenocepacia Virulence and Energy Metabolism by the Quorum-Sensing Signal BDSF and Its Synthase. J. Bacteriol. 191: 7270-7278 [Abstract] [Full Text]  


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