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Journal of Bacteriology, August 2009, p. 5301-5303, Vol. 191, No. 16
0021-9193/09/$08.00+0     doi:10.1128/JB.00427-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Feedback Regulation of Lac Repressor Expression in Escherichia coli{triangledown}

Stefan Oehler*

IMBB-FORTH, Nikolaou Plastira 100, GR-70013 Heraklion, Crete, Greece

Received 28 March 2009/ Accepted 29 May 2009

Negative feedback regulation, mediated through repressor binding site O3, which overlaps the lacI gene, could explain the robustness of the weak expression of Lac repressor. Significant autorepression of Lac repressor has never been ruled out. In the work presented here, the degree of autoregulation of Lac repressor was determined. It is negligible.

* Present address: Biomedical Sciences Research Center Alexander Fleming, 16672 Vari, Athens, Greece. Phone: 30-210-9656310-211. Fax: 30-210-9656-563. E-mail: oehler{at}fleming.gr

{triangledown} Published ahead of print on 5 June 2009.

Journal of Bacteriology, August 2009, p. 5301-5303, Vol. 191, No. 16
0021-9193/09/$08.00+0     doi:10.1128/JB.00427-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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