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Journal of Bacteriology, September 2009, p. 5849-5853, Vol. 191, No. 18
0021-9193/09/$08.00+0     doi:10.1128/JB.00539-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Isoprenoids Are Essential for Fruiting Body Formation in Myxococcus xanthus{triangledown}

Wolfram Lorenzen,1,2 Michael W. Ring,2 Gertrud Schwär,2 and Helge B. Bode1,2*

Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Goethe Universität Frankfurt, 60438 Frankfurt am Main, Germany,1 Pharmazeutische Biotechnologie, Universität des Saarlandes, 66123 Saarbrücken, Germany2

Received 22 April 2009/ Accepted 13 July 2009

It was recently shown that Myxococcus xanthus harbors an alternative and reversible biosynthetic pathway to isovaleryl coenzyme A (CoA) branching from 3-hydroxy-3-methylglutaryl-CoA. Analyses of various mutants in these pathways for fatty acid profiles and fruiting body formation revealed for the first time the importance of isoprenoids for myxobacterial development.

* Corresponding author. Mailing address: Molekulare Biotechnologie, Institut für Molekulare Biowissenschaften, Biozentrum/Campus Riedberg, Goethe Universität Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany. Phone: 49 69 798 29522. Fax: 49 69 798 29527. E-mail: h.bode{at}bio.uni-frankfurt.de

{triangledown} Published ahead of print on 17 July 2009.

Journal of Bacteriology, September 2009, p. 5849-5853, Vol. 191, No. 18
0021-9193/09/$08.00+0     doi:10.1128/JB.00539-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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